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    BroadPharm

    發布者:艾美捷科技    發布時間:2024-02-18 16:36:35     
    分享到:


    BroadPharm.png

    品牌官網:https://broadpharm.com/ 


    BroadPharm是一個領先的以客戶為中心的生物技術公司,總部位于圣地亞哥,BroadPharm致力于為全球客戶提供高質量的PEG接頭、Click Chemistry試劑、ADC接頭、 PROTAC接頭、藥物遞送脂質、核苷、亞磷酰胺和標記試劑。BroadPharm成立于2009年,生產超過2000種分散的,高純度的聚乙二醇(PEG)試劑,目前這些PEG試劑廣泛應用于生物偶聯、抗體-藥物偶聯(ADC)治療、藥物遞送和診斷領域。


    主要產品線:

    • PEG接頭

    • 點擊化學試劑

    • 標記染料

    • ADC接頭

     

    1. PEG接頭(PEG linker

    PEG連接劑,也稱為PEG試劑,是一種化學功能化的聚乙二醇(PEG)連接劑。由于其水溶性、無毒性、低免疫原性和明確的鏈長,PEG連接劑作為交聯劑在偶聯和生物標記方面特別有吸引力。 

    PEG化是將PEG連接體連接到藥物、蛋白質或囊泡等分子上的過程。由于其高水溶性和非免疫原性,PEG已被廣泛用于制藥和生物技術研發,以提高藥物的溶解度和穩定性,優化DMPK并發現新的遞送形式。BroadPharm的PEG-Linker代表一種高純度的特定單一純分子,這些單分散PEG是用設計的PEG長度和各種官能團設計的。 


    BroadPharm能夠提供的PEG接頭類型: 

    BroadPharm-1.png


    PEG接頭的結構: 

    BroadPharm-2.png


    2.點擊化學試劑(Click Chemistry):

    點擊化學已廣泛應用于制藥和生物技術研發。在第一代Click Chemistry,是在末端炔烴和疊氮化物之間的反應中需要Cu(I)作為催化劑。Cu(I)離子的毒性會對生物分子造成氧化損傷。第二代Click Chemistry采用應變促進疊氮-炔Click Chemistry,無需催化劑,具有生物相容性。與末端炔烴相比,應變環辛烯的活化能顯著降低。第三代Click Chemistry是四嗪和烯烴(反式環辛烯)之間的連接。這種高速反應也是不含銅的,這是體內細胞標記的理想選擇。    

    BroadPharm-3.png


    BroadPharm可提供的點擊化學試劑類型:   

    BroadPharm-4.png


    3.標記染料:

    熒光試劑已被用于標記蛋白質、抗體、核酸和其他生物物質,用于生物標記、細胞成像、診斷、蛋白質印跡和免疫組織化學。熒光染料可以連接到氨基(N)或羧基(C)末端,或者通過點擊化學進行連接。  


    BroadPharm可以提供的熒光基團類型:   

    BroadPharm-5.png


    4.ADC接頭: 

    抗體藥物結合物(ADC)是一類由抗體通過適當的連接子/接頭與藥物負載物鏈接在一起的高效生物藥物。連接劑分為可降解和不可降解兩個家族。         

    ① 可降解連接劑的ADC,以Adcetris(由Seattle Genetics推出)代表,其結構如下所示:   

    BroadPharm-6.png

    ② 對于不可降解連接劑的ADC,它依賴于ADC內部化后抗體的完全降解,以Kadcyla代表(由Genentech和Roche推出),其結構如下所示:     

    BroadPharm-7.png

    作為BroadPharm在中國的區域總代理,艾美捷科技有限公司將為中國客戶提供全面的BroadPharm的產品。下圖為BroadPharm公司授權艾美捷科技有限公司(AmyJet Scientific Inc.)作為BroadPharm在中國區域的代理授權書。

    BroadPharm-8.png

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    BP-40780endo-BCN-PEG4-Biotin10MG
    BP-40856endo-BCN-PEG2-Val-Cit-PAB-MMAE5MG


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